Researchers at Fudan University have conducted a detailed study on the levels of specific proteins in the blood to identify potential early warning signs of dementia. The study involved analyzing 1,463 types of plasma proteins in blood samples from 52,645 adults without a dementia diagnosis. Over the course of 14 years, common changes in blood serum were identified in the 1,417 patients who later developed different types of dementia, including Alzheimer’s disease. Four specific proteins were consistently present in the plasma of patients who would be diagnosed with dementia, namely glial fibrillary acidic protein (GFAP), neurofilament light polypeptide (NEFL), growth/differentiation factor 15 (GDF15), and latent-transforming growth factor beta-binding protein 2 (LTBP2).

The findings of this study have significant implications for screening individuals at high risk for dementia and for early intervention. Early detection of dementia through blood proteins could provide more time to slow down the progression of the disease, especially considering the lack of a cure for dementia. Individuals with higher levels of GFAP were found to be 2.32 times more likely to develop dementia, indicating the potential predictive power of these specific proteins.

While smaller studies have previously identified plasma proteins as potential biomarkers for dementia risk, these studies often compared individuals with and without dementia, rather than focusing on changes before the onset of dementia. This study’s large-scale and long-term nature overcame these limitations, providing a more accurate prediction of dementia risk. Notably, GFAP and LTBP2 were highly specific for predicting dementia, while NEFL and GDF15 showed changes in blood plasma levels up to a decade before dementia symptoms became evident.

The combination of specific blood proteins with basic demographic indicators proved to be an effective tool for predicting dementia risk even more than 10 years before diagnosis. If a simple blood test could indicate an individual’s risk of developing dementia, early interventions such as dietary adjustments and prescribed activities could potentially slow down the disease’s progression. This early detection method could also help families prepare for the challenges that lie ahead when dealing with dementia.

The study on blood proteins as early warning signs for dementia has the potential to revolutionize how we approach and manage this debilitating condition. By identifying specific proteins that indicate a higher risk of dementia, healthcare professionals can intervene earlier and provide targeted treatments to slow down the progression of the disease. Further research and validation of these findings could lead to the development of a reliable screening tool for dementia, ultimately improving the quality of life for individuals at risk and their families.


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