Depression has a long history, with its core experiences of changes in energy, activity, thinking, and mood being described for thousands of years. Despite this long history, experts still do not agree on a universal definition or cause of depression. It is seen as a large family of illnesses with different causes and mechanisms, making the process of choosing the best treatment for each individual challenging.

The classification of depression into sub-types, such as ‘reactive’ and ‘endogenous’, has been a common practice in clinical mental health. Reactive depression is believed to be triggered by external stressors, while endogenous depression is thought to be caused by internal factors such as genes or brain chemistry. While this classification may seem straightforward, it oversimplifies the complex nature of depression. Stressful life events and genetic factors interact in intricate ways to increase the risk of developing depression.

The Role of Genetics in Depression

A study conducted by the Australian Genetics of Depression found that genetic risk for mental disorders influences people’s reported exposure to stressful life events. Contrary to expectations, individuals with a higher genetic risk for depression, anxiety, ADHD, or schizophrenia reported being exposed to more stressors. This challenges the conventional notion that individuals with a lower genetic component (reactive group) would experience more stressful life events, while those with a higher genetic component (endogenous group) would experience fewer stressors.

Genes, Environments, and Depression

Genetic risk for mental disorders plays a significant role in how individuals perceive and react to their environments. It affects their sensitivity to external stressors and can influence the environments they find themselves in. Individuals with a higher genetic vulnerability may be more prone to experiencing stressful life events and getting into dysfunctional relationships. This complex interplay between genes and environments suggests that depression is not simply a result of genetics or stressors alone, but a combination of both.

The study’s findings suggest that a distinction between reactive and endogenous depression may not be as clear-cut as previously thought. Most cases of depression are likely a combination of genetic predisposition, biological factors, and exposure to stressors. Individuals with a higher genetic vulnerability to depression may benefit from learning specific techniques to manage stress. This could help reduce the risk of developing depression and alleviate ongoing exposure to stressful life events.

The relationship between genes, environments, and depression is a complex and multifaceted one. Understanding how genetic risk for mental disorders influences an individual’s exposure to stressors provides valuable insights into the development and management of depression. By recognizing the intricate interplay between genetics, biology, and environmental factors, clinicians can tailor treatments to address the unique needs of each individual struggling with depression.


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